GST‐7T and P‐170 co‐expression in multiple myeloma

Publisher Website
Google Scholar
Abstract
Summary. Bone marrow samples from 40 patients affected by multiple myeloma either treated or untreated were examined for expression of glutathione‐S‐transferase n (GST‐TT), P‐glycoprotein and the protein product of ras oncogenes family, p‐21, on plasma cells, by immuno‐cytochemical detection. 72% of evaluated samples were positive for P‐170 and 82% for GST‐7T without any correlation with clinical or prognostic parameters. A significant relationship between GST‐7T expression and P‐l 70 positivity was found and co‐expression was observed in 91% of evaluated samples.Expression of P‐170 and GST‐TT was found both in treated and untreated patients. However, patients evaluated before and after therapy showed an increase in the percentage of plasma cells positive for GST‐7T or P‐170 or both. Expression of p‐21 was not associated with these mechanisms of drug resistance.These data suggest that different resistance mechanisms are present in multiple myeloma.

This publication has 19 references indexed in Scilit: