Effect of Virus Dose and Nonoxynol‐9 on the Genital Transmission of SIV in Rhesus Macaques
- 1 May 1990
- journal article
- research article
- Published by Wiley in Journal of Medical Primatology
- Vol. 19 (3-4) , 401-409
- https://doi.org/10.1111/j.1600-0684.1990.tb00445.x
Abstract
One inoculation of cell‐free SIVMAC‐ (50 TC1D50) caused persistent viremia in nine of 13 female rhesus macaques inoculated intravaginally. Persistent viremia was produced in two of four male rhesus macaques by twice placing cell‐free SIVMAC (50 TCID50) onto the skin and urethral os of the penis. Placing a spermicide containing nonoxynol‐9 into the vaginal canal prior to repeated intravaginal inoculations of SIV prevented transmission of the virus in three of six female rhesus macaques.Keywords
Funding Information
- U.S. Public Health Service (RR00169, NO1‐AI‐62559)
- U.S. Army Medical Command (87‐PP‐7863)
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