Origin of Testicular Teratomas From Primordial Germ Cells in Mice2
Open Access
- 1 April 1967
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 38 (4) , 549-552
- https://doi.org/10.1093/jnci/38.4.549
Abstract
Teratomas were experimentally induced in testes of strain 129 mice when 12½-day genital ridges from fetuses were grafted into the testes of adults. Seventy-five percent of 194 testes developing from implanted SIJ/+, SId/+, and +/+ genital ridges contained teratomas. These gonads had normal numbers of primordial germ cells. In contrast, only 3% of 75 SIJ/SIJ and SId/SId testes contained teratomas. These gonads had very few primordial germ cells. This finding supports strongly the hypothesis that testicular teratomas in mice are derived from primordial germ cells.Keywords
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