Activity of ciprofloxacin against genital tract pathogens.

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Abstract
The in vitro activity of the quinolone carboxylic acid, ciprofloxacin, against a variety of genital tract pathogens was examined. Each of 35 isolates of Neisseria gonorrhoeae, including some .beta.-lactamase-producing strains and strains resistant to tetracycline, was inhibited at a concentration of 0.01 mg/l. Most (13 of 20) strains of Gardnerella vaginalis were inhibited at 1 mg/l but 3 isolates had minimum inhibitory concentrations (MIC) of .gtoreq. 8 mg/l. Each of 7 strains of Chlamydia trachomatis was completely inhibited at a concentration of 2 mg/l. Prolonged (72 h) exposure of the chlamydiae to ciprofloxacin was required for inhibition at this concentration.