USE OF FLUORESCENT ANTIBODY STAINING IN DIAGNOSIS OF RABIES

  • 1 January 1965
    • journal article
    • research article
    • Vol. 29  (6) , 141-+
Abstract
Brain material from 750 domestic and wild animals submitted to this laboratory for rabies diagnosis was studied by the following three methods: a) microscipic examination of Williams'' stained impression, b) mouse inoculation test, and c) microscopic examination of impressions stained with fluorescein-tagged antibodies. From the results obtained by one or the other method of study, 175 specimens were diagnosed as positive. Of these, only 58 (33 percent) were detected by the examination of Williams'' stained impression. On the other hand, two rabid cases were missed by the mouse inoculation test, and four by the fluorescent antibody technique. Without being completely reliable, the last two methods proved to be almost equally sensitive and much more so than the examination of Williams'' stained impressions.