Inactivation of poliovirus and other enteroviruses by solutions of sodium fluoride at low pH

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Abstract
Solutions of NaFl at pH 3-4 inactivated enteroviruses [poliovirus type 1, echovirus type 4 and coxsackievirus B3], whereas other sodium salts had little or no effect on virus infectivity. Solutions of KFl also inactivated viruses under similar conditions. Light, temperature and the presence of organic compounds such as detergents and [human] fecal matter did not affect inactivation of virus by 0.4 M solutions of NaFl at pH 3-4. Decreasing the NaFl concentration below 0.04 M or raising the pH above 4 reduced the viricidal properties of the solutions. Virus adsorbed to membrane filters and sludge flocs could not be recovered after treatment of solids-associated virus with solutions of NaFl.