Peripheral Unresponsiveness to Human Growth Hormone in Laron Dwarfism

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Abstract
IN 1966 Laron and his associates described a severe form of dwarfism associated with high levels of circulating immunoreactive human growth hormone.1 Laron dwarfism is usually a familial disorder, and affected persons are generally resistant to the effects of endogenous or exogenous growth hormone.2 3 4 5 6 7 Current evidence suggests that the circulating growth hormone in Laron dwarfs is immunochemically and biochemically normal.7 8 9 Furthermore, Jacobs et al. have found that the endogenous growth hormone in affected persons binds normally in radioreceptor assays.10 It has therefore been postulated, but not demonstrated, that the syndrome of Laron dwarfism is due to end-organ unresponsiveness to growth . . .