Studies on Maturation And Crosslinking of Collagen Implants in Hypophysectomized RatsIn Vivo

Publisher Website
Google Scholar
Abstract
Quantitative analysis of electrophoretically separated heat-denatured collagen showed that crosslinking of thermally reconstituted native non-crosslinked collagen fibers was inhibited following implantation with a diffusion chamber into hypophysectomized rats. Comparative studies on collagen extractability from the skin of hypophysectomized rats and their normal pair-fed and ad lib. controls showed that both age and food restriction had no effect on collagen maturation when the pituitary gland had been removed. The results indicate that hypophysectomy inhibits the first step in intramolecular crosslinking of collagen by affecting the production and/or the activity of lysyl oxidase which may be a pituitary gland hormone dependent enzyme.

This publication has 23 references indexed in Scilit: