Regional variations in intracranial iodide transport

Publisher Website
Google Scholar
Abstract
Transfer of radioactive sodium iodide131 in trace doses in the anesthetized dog has been studied by externally monitoring the radioactivity after injection into different regions of the cerebral ventricles, intracranial meningeal spaces, and parasagittal cerebral cortex. Transfer is rapid from lateral, 3rd, and 4th ventricles and is greatly slowed at all 3 sites by local or systemic injections of perchlorate. An active or carrier mechanism of transport is implicated. The relative roles of ependyma and choroid plexus in this transfer remain unexplored. Transfer is similarly rapid from the parasagittal subdural space, but here perchlorate produces no significant slowing. These data do not support the possibility that a carrier mechanism is involved. The similar behavior of I131 after its application to the exposed dorsal surface of the superior sagittal sinus or to the perifalcial subdural space suggests that direct transfer across the walls of blood vessels is involved in the movement from the subdural space. Transfer is slower after intracortical injection but still quite rapid. Perchlorate does not reliably slow this movement. Thus, although a cerebral carrier process may be present, the data are not adequate, to confirm it with the present technique.

This publication has 3 references indexed in Scilit: