Effects of Hypoxemia upon Aminoglycoside Serum Pharmacokinetics in Animals

1 September 1978

journal article
research article
Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy

Vol. 14 (3) , 344-347
https://doi.org/10.1128/aac.14.3.344

Abstract

Hypoxemia causes significant alterations in aminoglycoside serum pharmacokinetics in adult rats and newborn rabbits. The aminoglycoside serum clearances were diminished in hypoxemic animals. Comparisons of intravenous and intramuscular administration imply a delay in uptake of drug from intramuscular injection sites under hypoxemic conditions.

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