A Randomized Trial of the Discontinuation of Primary and Secondary Prophylaxis againstPneumocystis cariniiPneumonia after Highly Active Antiretroviral Therapy in Patients with HIV Infection
- 18 January 2001
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 344 (3) , 159-167
- https://doi.org/10.1056/nejm200101183440301
Abstract
Prophylaxis against Pneumocystis carinii pneumonia is indicated in patients with human immunodeficiency virus (HIV) infection who have less than 200 CD4 cells per cubic millimeter and in those with a history of P. carinii pneumonia. However, it is not clear whether prophylaxis can be safely discontinued after CD4 cell counts increase in response to highly active antiretroviral therapy.Keywords
This publication has 31 references indexed in Scilit:
- Atovaquone Compared with Dapsone for the Prevention ofPneumocystis cariniiPneumonia in Patients with HIV Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, or BothNew England Journal of Medicine, 1998
- Intermittent Trimethoprim-Sulfamethoxazole Compared with Dapsone-Pyrimethamine for the Simultaneous Primary Prophylaxis of Pneumocystis Pneumonia and Toxoplasmosis in Patients Infected with HIVAnnals of Internal Medicine, 1995
- The tolerance for zidovudine plus thrice weekly or daily trimethoprim-sulfamethoxazole with and without leucovorin for primary prophylaxis in advanced HIV diseaseThe American Journal of Medicine, 1995
- A Controlled Trial of Aerosolized Pentamidine or Trimethoprim–Sulfamethoxazole as Primary Prophylaxis againstPneumocystis cariniiPneumonia in Patients with Human Immunodeficiency Virus InfectionNew England Journal of Medicine, 1992
- A comparison of the effectiveness of three regimens in the prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected patientsArchives of internal medicine (1960), 1992
- Aerosol Pentamidine for Secondary Prophylaxis of AIDS-related Pneumocystis carinii PneumoniaAnnals of Internal Medicine, 1991
- Intermittent co-trimoxazole prophylaxis against Pneumocystis carinii pneumoniaThe Lancet, 1990
- The Risk ofPneumocystis cariniiPneumonia among Men Infected with Human Immunodeficiency Virus Type 1New England Journal of Medicine, 1990
- From the Centers for Disease Control. Guidelines for prophylaxis against Pneumocystis carinii pneumonia for persons infected with human immunodeficiency virusPublished by American Medical Association (AMA) ,1989
- Safety and efficacy of sulfamethoxazole and trimethoprim chemoprophylaxis for Pneumocystis carinii pneumonia in AIDSJAMA, 1988