Anemia and the Spleen

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Abstract
THE spleen has come to be known as an organ of phagocytosis and antibody production. It appears admirably suited for these functions, since it is located in the direct stream of the circulating blood and composed for the most part of macrophages, plasma cells and lymphocytes. Although its functions remain inconspicuous in the normal subject, an extensive literature attests to its effects on the formed elements of the blood in pathologic states. Data concerning leukocytes and thrombocytes appear so fragmentary that the present discussion is limited to the consideration of splenic-erythrocyte relations.Explanations of the mechanisms whereby anemia is produced . . .