Metabolism of O,O‐dimethyl‐O‐(3,5,6‐trichloro‐2‐pyridyl) phosphorothioate in sheep and rats and of 3,5,6‐trichloro‐2‐pyridinol in sheep

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Abstract
Sheep and rats metabolized single oral doses of O‐O‐dimethyl‐O‐(3,5,6‐trichloro‐2‐pyridyl) phosphorothioate (I) to three major metabolites that were excreted in the urine (approximately 70% of the 14C) . These were the glucuronide of 3,5,6‐trichloro‐2‐pyridinol, O‐methyl‐O‐(3,5,6‐trichloro‐2‐pyridyl) phosphorothioate, and 3,5,6‐trichloro‐2‐pyridinol. The latter two metabolites and the parent compound were isolated from sheep feces. Sheep plasma contained the same metabolites that were found in sheep urine, and no parent compound was detected in the plasma. Tissue residues from I were determined. Visceral fat contained the highest concentration of I‐equivalents (11.8 ppm). Sheep excreted a single oral dose of 3,5,6‐trichoropyridinol (II) unchanged in the feces and as II‐glucuronide in the urine.