EXPERIMENTALLY INDUCED HYPERTENSION IN PARABIOTIC RATS

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Abstract
Rats were joined in parabiotic union and their systolic blood pressures detd. daily following operative procedures on the kidney. Parabiotic individuals retain an independence of their circulatory adjustments; hypertensive blood pressure levels may be maintained in one member of a parabiotic pair, while the blood pressure of the co-twin remains normal. In some instances, however, the hypertensive action induced by procedures on the kidney is transmitted to the intact co-twin. The results are interpreted as being most consistent with the view that the kidney normally elaborates a substance necessary for the maintenance of normal blood pressure levels. The bearing of the results on other current theories of the pathogenesis of exptl. renal hypertension is discussed. The results are incompatible with the view that a pressor substance is present in the blood in any high conc. as has been claimed.

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