In VitroAldosterone Production by Adrenals of Normal Recipient Rats Cross-Circulated with Rats with Secondary Hyperaldosteronism of Dietary Sodium Restriction

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Abstract
The in vitro aldosterone production rates of adrenals of normal recipient rats cross-circulated with sodium-deficient donors previously subjected to a low-sodium diet for 14 days were studied. Results showed that the in vitro aldosterone production rate of adrenals of recipients obtained after cross-circulation with intact, sodium-deficient donors did not change significantly from that of control glands obtained before establishing cross-circulation, although the adrenals of donor animals secreted significantly greater amounts of aldosterone than those of normal rats. A slight increase was observed when the adrenals of recipient rats obtained after cross-circulation with adrenalectomized (18–20 hr), sodium-deficient donors were incubated in vitro, but the increase was not statistically significant and the concomitant increase in the total corticosteroid secretion rates by these same adrenals indicated that the slight increase is probably attributable to the compensatory increase of ACTH circulating in the blood of adrenalectomized animals. Although the present finding demonstrated an apparent nontransferability of the aldosterone stimulus present in sodium-deficient rats, it does not preclude the existence of a humoral mechanism mediating the aldosterone response to dietary sodium restriction in the rat. Several possible explanations may account for the data obtained. (Endocrinology80: 221, 1967)