Developing Standardized Behavioral Tests for Knockout and Mutant Mice
Open Access
- 1 January 2000
- journal article
- review article
- Published by Oxford University Press (OUP) in ILAR Journal
- Vol. 41 (3) , 163-174
- https://doi.org/10.1093/ilar.41.3.163
Abstract
The ability to produce transgenic, knockout, and mutant mice provides new animal models for the genetic analysis of behavior and its underlying neural mechanisms ( Chen and Tonegawa 1997 ; Wehner et al. 1996 ). Knockout and transgenic mice have been developed as animal models for the study of human diseases such as Alzheimer’s disease (Flood and Morley 1998 ; Nalbantoglu et al. 1997 ), Down’s syndrome ( Schuchmann et al. 1998 ; Tremml et al. 1998 ), Huntington’s disease ( Bates et al. 1997 ), schizophrenia ( Mohn et al. 1999 ), and other neurobiologic disorders ( Nelson and Young 1998 ). Transgenic mice can also be used to study the behavioral effects of altering specific neurochemical receptors such as for N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxasole-propionate ( Sprengel and Single 1999 ), metabotropic glutamate ( Galani et al. 1997 ), serotonin ( Parks et al. 1998 ), or dopamine ( Steiner et al. 1997 ).Keywords
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