Updates on p53: modulation of p53 degradation as a therapeutic approach
Open Access
- 8 January 2008
- journal article
- review article
- Published by Springer Nature in British Journal of Cancer
- Vol. 98 (1) , 4-8
- https://doi.org/10.1038/sj.bjc.6604098
Abstract
The p53 pathway is aberrant in most human tumours with over 50% expressing mutant p53 proteins. The pathway is critically controlled by protein degradation. Here, we discuss the latest developments in the search for small molecules that can modulate p53 pathway protein stability and restore p53 activity for cancer therapy.Keywords
This publication has 79 references indexed in Scilit:
- Nearly complete rRNA genes assembled from across the metazoan animals: Effects of more taxa, a structure-based alignment, and paired-sites evolutionary models on phylogeny reconstructionMolecular Phylogenetics and Evolution, 2010
- Multiple Alignment of DNA Sequences with MAFFTPublished by Springer Nature ,2009
- PCR survey of Xenoturbella bocki Hox genesJournal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2007
- The mitochondrial DNA of Xenoturbella bocki: genomic architecture and phylogenetic analysisTheory in Biosciences, 2007
- MDM2 and MDM4: p53 regulators as targets in anticancer therapyPublished by Elsevier ,2007
- Ultrastructural and immunocytochemical investigation of acoel sperms with 9 + 1 axoneme structure: new sperm characters for unraveling phylogeny in AcoelaZoomorphology, 2006
- The dawn of bilaterian animals: the case of acoelomorph flatwormsBioEssays, 2004
- Functional morphology of musculature in the acoelomate worm, Convoluta pulchra (Plathelminthes)Zoomorphology, 1999
- What can molecular genetics contribute to marine biogeography? An urchin's taleJournal of Experimental Marine Biology and Ecology, 1996
- Is the Turbellaria polyphyletic?Hydrobiologia, 1986