Modulation of substance P-induced bronchoconstriction by lipoxygenase metabolites
- 1 May 1985
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 37 (5) , 345-347
- https://doi.org/10.1111/j.2042-7158.1985.tb05079.x
Abstract
In anaesthetized, mechanically ventilated guinea-pigs, substance P induces a bronchoconstrictor response comprising increases in airway resistance and decreases in dynamic compliance. Eicosatetraynoic acid (ETYA, 20 mg kg−1 i.v.) or BW755c (20 mg kg−1 i.v.) potentiated the substance P-induced bronchoconstriction. Neither indomethacin (1 or Smgkg-' i.v.) nor aspirin (20 mg kg−1 i.v.) significantly altered the potency of substance P on bronchomotor responses. These observations are consistent with the existence of a bronchodilator lipoxygenase metabolite(s).Keywords
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