The Dreywood Anthrone Reaction as Affected by Carbohydrate Structure

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Abstract
The hairwas clipped from the dorsolateral aspect and adjacent regions of the neck of albino rats, at weekly intervals. Extent of replacement on the denuded area was recorded by sketches and photographs. The rats were divided into 3 groups, and treated daily by applying material onto the dorsal neck skin with a tuberculin syringe and rubbing the skin lightly. Five animals of Group 1 received 0.1 ml. of adrenal cortical extract; 13 animals of Group 2 received 0.1 mg. of 11-dehydro-17-hydroxy-cortico-sterone in 0.1 ml. of 25% ethyl alcohol; and 8 rats of Group 3 served as controls. Within 3 wks. of treatment, hair replacement ceased locally in animals of Group 2. Inhibition also occurred, to a lesser degree, in animals of Group 1. No detectable change in the rate of hair replacement occurred with 25% alcohol in the controls. At least one of the 11-oxysteroid hormones of the adrenal cortex exerts a depressing effect on hair growth in the rat.