Quantitative Assessment of Erythropoiesis in Haemolytic Disease

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Abstract
Erythrokinetic parameters were estimated in 21 patients suffering from hemolytic disease using a mathematical model of Fe kinetics. A proper definition of radio Fe reflux from red cells to the plasma proved to be essential for an accurate estimate of effective and ineffective erythropoiesis in severe hemolytic conditions. Erythropoietic activity was increased in all the patients, with the bone marrow capable of sustaining erythropoiesis at about 6 times normal in hereditary spherocytosis and 3 times normal in autoimmune hemolytic anemia. This proliferative effort was countered by an increase in ineffective erythropoiesis which was especially marked in hereditary spherocytosis.