PROTECTIVE EFFECT OF INTRA-PERITONEAL SPLENIC AUTO-TRANSPLANTS IN MICE EXPOSED TO AN AEROSOLIZED SUSPENSION OF TYPE-III STREPTOCOCCUS-PNEUMONIAE

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (2) , 354-358
Abstract
Splenosis occurs after traumatic injury to the spleen. This may be the mechanism for the low incidence of bacterial infection in this group of patients when compared to those who undergo splenectomy for other reasons. The effect of exposure to an aerosolized suspension of type III S. pneumoniae on splenectomized mice who had all or half of their splenic tissue cut up and reimplanted into the abdominal cavity 8 wk prior to bacterial exposure was studied. The mortality experience of these 2 groups of mice was similar to each other and no different from the sham control group, although all 3 groups had a statistically significant lower mortality experience than the splenectomized control group. Splenosis in mice can protect against aerosolized bacterial infection.