ANTIBODY-RESPONSE TO INTRAVENOUS IMMUNIZATION FOLLOWING SPLENIC TISSUE AUTOTRANSPLANTATION IN SPRAGUE-DAWLEY RATS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 49  (5) , 779-783
Abstract
The response to i.v. challenge with sheep erythrocytes was determined in Sprague-Dawley rats following autotransplantation of splenic tissue into the subcutaneous tissue, peritoneal cavity or a surgically created omental pouch. There was a marked rise in heterophile antibody titer following i.v. challenge in 10 control animals, and no rise in titer in 9 of 10 asplenic animals. Heterophile antibody titers increased in all of the animals with transplants, but the response in some was less than that in control animals. Autotransplanted splenic tissue demonstrated immunologic responses similar to those of normal, intact spleen.

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