Long-Term Fluoxetine Treatment of a Large Number of Obsessive-Compulsive Patients

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Abstract
A group of 75 outpatients suffering from obsessive-compulsive disorder began treatment with the bi-cyclic antidepressant fluoxetine in an open clinical setting. Their progress was evaluated using the Hamilton Depression Scale, the Hamilton Anxiety Scale, and a global scale of severity of obsessive-compulsive symptoms. The group showed significant improvement on all measures. This improvement continued and was progressive over a 5-month period. Weight loss was present but not significant by the end of the 5-month period.