Strand scissions of DNA by patulin in the presence of reducing agents and cupric ions.
- 1 January 1987
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 40 (5) , 692-696
- https://doi.org/10.7164/antibiotics.40.692
Abstract
In the presence of NADPH and CuCl2, patulin induced the cleavage of ColE1 DNA and .lambda. phage DNA in vitro. The DNA-cleaving activity of patulin was concentration dependent. At the lowest concentration of patulin, ColE1 supercoiled DNA was relaxed and the highest concentration induced linearization of the DNA. This activity was inhibited by superoxide dismutase, catalase and radical scavengers, showing involvement of free radicals in the DNA-cleavage. .lambda. Phage DNA was also degraded by patulin under the same conditions.This publication has 7 references indexed in Scilit:
- DNA-damaging activity of patulin in Escherichia coliApplied and Environmental Microbiology, 1986
- Mechanism of action of dnacin B1, a new benzoquinoid antibiotic with antitumor propertiesAntimicrobial Agents and Chemotherapy, 1982
- DNA strand scission induced by adriamycin and aclacinomycin A.The Journal of Antibiotics, 1979
- Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxinsMutation Research/Genetic Toxicology, 1978
- Evaluation of the mutagenic potential of mycotoxins using Salmonella typhimurium and Saccharomyces cerevisiaeMutation Research/Environmental Mutagenesis and Related Subjects, 1978
- Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agentsBiochemical and Biophysical Research Communications, 1977
- MUTAGENICITY AND INDUCIBILITY OF DNA SINGLE-STRAND BREAKS AND CHROMOSOME-ABERRATIONS BY VARIOUS MYCOTOXINS1977