CUSHING'S SYNDROME WITH ATYPICAL BIOCHEMICAL RESULTS

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Abstract
A case of Cushing''s syndrome is described with bilateral adrenal hyperplasia. Basal excretion of urinary total 17-OHCS and 17-KS were within the normal range, but the excretion of 17-OHCS was not suppressed by 16 mg dexamethasome daily in divided doses for 5 days. The adrenal glands were stimulated normally by corticotrophln and the hypophysis by cortisol lack. The blood corticotrophin was estimated to be not significantly different from the levels found in normal persons. It is concluded that the failure of suppression indicates either that the adrenal glands were functioning in part autonomously or more likely that the pituitary corticotrophin regulating mechanism was more completely disturbed than is usually found in Cushing''s syndrome, due to bilateral adrenal hyperplasia.

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