Treatment of Chronic Plaque Psoriasis by Selective Targeting of Memory Effector T Lymphocytes
Top Cited Papers
Open Access
- 26 July 2001
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 345 (4) , 248-255
- https://doi.org/10.1056/nejm200107263450403
Abstract
Psoriatic plaques are characterized by infiltration with CD45RO+ memory effector T lymphocytes. The recombinant protein alefacept binds to CD2 on memory effector T lymphocytes, inhibiting their activation.Keywords
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