Multicenter Evaluation of a Semiautomated, Standardized Assay for Detection of Hepatitis B Virus DNA in Blood Donations
Open Access
- 1 June 2005
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 43 (6) , 2991-2993
- https://doi.org/10.1128/jcm.43.6.2991-2993.2005
Abstract
We evaluated the COBAS Ampliscreen hepatitis B virus (HBV) test using standards, seroconversion panels, consecutive donations, and samples from patients with abnormal alanine aminotransferase and chronic hepatitis C. Specificity was 100% and sensitivity was 20 IU/ml. In seroconversion panels, HBV DNA was detected up to 4 to 18 days before HBsAg, suggesting that this assay is useful in shortening the infectious window phase.Keywords
This publication has 14 references indexed in Scilit:
- Superiority of minipool nucleic acid amplification technology for hepatitis B virus over chemiluminescence immunoassay for hepatitis B surface antigen screeningVox Sanguinis, 2003
- Current and Emerging Infectious Risks of Blood TransfusionsJAMA, 2003
- Transfusion risks of yesterday and of todayTransfusion Clinique et Biologique, 2003
- Assessing the accuracy of three viral risk models in predicting the outcome of implementing HIV and HCV NAT donor screening in Australia and the implications for future HBV NATTransfusion, 2002
- Current prevalence and incidence of infectious disease markers and estimated window‐period risk in the American Red Cross blood donor populationTransfusion, 2002
- Residual risk of transfusion‐transmitted HCV and HIV infections by antibody‐screened blood in ItalyTransfusion, 2002
- Trends in residual risk of transfusion‐transmitted viral infections in France between 1992 and 2000Transfusion, 2002
- Estimated risk of transfusion-transmitted viral infections in SpainTransfusion, 2002
- The incidence/window period model and its use to assess the risk of transfusion-transmitted human immunodeficiency virus and hepatitis C virus infectionTransfusion Medicine Reviews, 1997
- Estimated Risk of Transmission of the Human Immunodeficiency Virus by Screened Blood in the United StatesNew England Journal of Medicine, 1995