Thrombocytopenia Occurring During the Administration of Heparin

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Abstract
In a group of 52 patients receiving continuous i.v. heparin, 16 developed thrombocytopenia (platelets < 100,000/mm3). Ten of the 16 patients who had thrombocytopenia had elevated titers of fibrinogen-fibrin degradation products and 5 of these 10 patients also had a reduction in plasma fibrinogen. The abnormalities disappeared after the heparin preparation was discontinued. These occurrences could not be attributed to drugs other than heparin, to the dose of heparin administered or to prior exposure to heparin. The mechanism by which the heparin preparation may induce these changes is not known.