Apo E 2 phenotypes in type II diabetics with and without insulin therapy

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Abstract
In 106 type II diabetics with persisting hyperlipidemia (i.e persistently increased triglycerides >200 mg/dl during intensive diabetes therapy) the Apo E polymorphism was examined in relation to IDDM (n=68) and NIDDM (n=38). It was shown that Apo E2 phenotypes are more (22.6% vs. 14.5%,ppppp<0.025). Regarding blood lipids there was an increase in total cholesterol due only to VLDL cholesterol in IDDM as well as in NIDDM. It is concluded that in spite of similar hyperlipidemias in type II diabetics the increase in Apo E2 phenotypes is different; it is induced by heterozygotes in IDDM and by homozygotes in NIDDM.