The neurokinin-1 receptor antagonist, sendide, exhibits antinociceptive activity in the formalin test
- 1 February 1995
- journal article
- Published by Wolters Kluwer Health in Pain
- Vol. 60 (2) , 175-180
- https://doi.org/10.1016/0304-3959(94)00107-p
Abstract
He mouse paw formalin test. Intrathecal administration of sendide (in pmol) reduced both the early and late phases of the formalin-induced licking response. [D-Trp7]sendide also produced a significant antinociceptive response with less potent activity than sendide. Even highest doses (4000 pmol sendide and 8000 pmol [D-Trp7]sendide) examined, there was no motor paralysis of the hindlimbs. Intrathecal morphine inhibited both the early and late phases of the formalin-induced licking response in a dose-dependent manner. The results indicate that the antinociceptive effects of sendide and [D-Trp7]sendide may be mediated at NK1 receptors in the formalin-induced nociception. ∗Corresponding author: Dr. Tsukasa Sakurada, Department of Pharmacology, Tohoku College of Pharmacy, 4-4-1 Komatsushima, Sendai 981, Japan. Tel: (022) 234-4181; FAX: (022) 275-2013. (Received 2 March 1994; revision received 28 April 1994; accepted 4 May 1994.) © Lippincott-Raven Publishers....Keywords
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