Clinical Experience with Steroid‐Eluting Unipolar Electrodes

Publisher Website
Google Scholar
Abstract
In continuing search of low chronic threshold leads, a new concept of electrode design which is capable of delivering corticosteroids at the myocardial tissue interface has been made available by Medtronic. Twenty‐three patients, 17 females and 6 males, were either implanted with 4003 (n = 21) or 5023 (n ‐ 2) steroid‐eluting electrodes in the ventricular chamber. Pacing modes utilized were WIM (n = 13) or DDD (n = 10). Pulse generators used were Medtronic (7005. 8317, 8329) Pacesetter (285) and Intermedics (283). Thresholds at the time of implantation at 0.50 msec pulse width were 0.40 ± 0.02 volts at 0.66 ± 0.05 milliamps. Resistance and R wave measured were 565.43 ± 22.07 ohms and 9.24 ± 1.06 mv, respectively. Chronic thresholds were checked on routine follow‐up visits by either decreasing pulse width and for pulse amplitude. Data is being reported between 1 and 88 (23.22 ± 4.35) weeks. Pulse width threshold at 2.5 volts were 0.10 msec (n = n) and 0.05 msec or lower (n = 12). At 5.0 volts no loss of capture was seen at 0.05 msec (n = 22) except in one patient at 0.10 msec. Pulse width thresholds in the first 24 weeks were lower than 0.20 msec at 2.5 volts (n = 15) and less than 0.70 msec, at 0.8 volts (n = 6). No loss of sensing was seen by electrocardiographic analysis at the time of threshold checks with the pulse generator at standard setting of the R wave. Thus, in this initial report, the steroid‐eluting electrodes have demonstrated very low thresholds both in the early and chronic follow‐up phase. Demonstration of consistently low thresholds, avoiding initial peaking, will permit routine low output setting without compromising safety and thus prolong the life of the pulse generators.