LITHIATION OF AN IMIDAZOLE NUCLEOSIDE AT THE C-5 POSITION. SYNTHESIS OF 3-DEAZAGUANOSINE FROM URIDINE
- 5 May 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 14 (5) , 589-592
- https://doi.org/10.1246/cl.1985.589
Abstract
3-Deazaguanosine, an antiviral nucleoside, was synthesized from uridine via lithiation of a C-2 protected imidazole nucleoside, which has been devised as a method for introducing various functionalities to the C-5 position. This furnished the first successful example of the conversion of a naturally occurring nucleoside to a deazapurine nucleoside.Keywords
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