Synthetic uses of steroidal ring B diene protection: 22,23-dihydroergosterol
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 8,p. 821-826
- https://doi.org/10.1039/p19760000821
Abstract
Protection of the ring B diene system of ergosterol by (i) a two-step addition of the elements of water across the 5,6-double bond, (ii) formation of the 4-phenyl-1,2,4-triazoline-3,5-dione adduct, or (iii) formation of the iron tricarbonyl adduct by treatment with p-methoxybenzylideneacetonetricarbonyliron, allowed selective reduction of the 22,23-double bond by catalytic or, as appropriate, ionic hydrogenation. Regeneration of the 5,7-diene system in each case gave a high yield of 22,23-dihydroergosterol.This publication has 1 reference indexed in Scilit:
- Unsaturated steroids. Part I. Synthesis of 22,23-dihydroergosterolJournal of the Chemical Society, Perkin Transactions 1, 1976