Normal Human Sera Cytotoxic to Cells of Human Acute Leukemia

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Abstract
Eight human sera, from healthy individuals with no history of immunization with human transplantation antigens, have demonstrated complement dependent cytotoxicity to cells of some patients with active acute leukemia. The antigen(s) detected by these sera are absent from normal and remission lymphocytes and appear most often in ALL [acute lymphocytic leukemia] patients with a high peripheral lymphoblast count. Some B [bone marrow-derived] and T [thymus-derived] lymphoblastoid cell lines carry the antigen(s), as evidenced by their ability to react with and absorb tha antileukemia activity. At least 2 overlapping specificities (detected by these antileukemia sera) apparently exist. The leukemia antigen(s) show no strong correlation with any known HL-A antigen. A human leukemia blast associated antigen or set of antigens are apparently present which may be immunogenic in man. Their relationship to normal HL-A antigens of loci other than A, B or C is unknown.