Functional assay of cytotoxic lymphocytes involved in antibody-mediated cytotoxicity in normal and rheumatoid subjects.
Open Access
- 1 June 1977
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 36 (3) , 257-260
- https://doi.org/10.1136/ard.36.3.257
Abstract
Antibody-mediated lymphocyte-induced cytotoxicity (K cell activity) was measured in a system consisting of Chang human liver cells, rabbit anti-Chang antiserum, and Triosil-Ficoll purified human lymphocytes. It was concluded that one K cell probably inactivates or kills one target cell, and that the number of active K cells is similar in the peripheral blood of normal and rheumatoid subjects and is about 0-5%.This publication has 4 references indexed in Scilit:
- Functional fractionation of human cytotoxic cells using differences in their cation requirementsNature, 1975
- Reduced antibody-dependent cell-mediated cytotoxicity in systemic lupus erythematosus.1975
- Antibody dependent cytolytic effector lymphocytes (K cells) in human blood.1975
- Deficient Lymphoid Cell‐Mediated, PHA‐Induced Cytotoxicity in Rheumatoid Arthritis PatientsScandinavian Journal of Immunology, 1975