URINARY PREGNANEDIOL ESTIMATION AS A TEST FOR PREGNANCY

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Abstract
Since the pioneer work of Venning & Browne [1937] on pregnanediol excretion a number of attempts have been made to use the estimation of pregnanediol in the urine as a pregnancy test. The earlier workers followed Venning & Browne's method and isolated the glycuronidate from 24 hr. urine specimens [Hain & Robertson, 1939; Wilson & Randall, 1939; Buxton, 1940; Cope, 1940]. These workers reported favourably on the possibilities of the test but the method was laborious and time-consuming; it has also been criticized on purely chemical grounds by Marrian & Gough [1946]. The later method of Astwood & Jones [1941], in which free pregnanediol is isolated after hydrolysis of the urine, presents great technical advantages and was further modified by Talbot, Berman, McLachlan & Wolfe [1941]. This has been called the 'Astwood-Talbot' method by Sommerville, Gough & Marrian [1948] who have just published a further modification of it. Using a

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