Toward Understanding How the Lactone Moiety of Discodermolide Affects Activity
- 13 April 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (18) , 6532-6533
- https://doi.org/10.1021/ja051185i
Abstract
A series of simplified discodermolide analogues have been designed and synthesized in an attempt to understand the role of the lactone ring. These synthetic efforts have led to an unsubstituted butyrolactone 9 being generated, which shows improved activity over the natural product.Keywords
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