Rat Corticotropin-Releasing Hormone Gene: Sequence and Tissue-Specific Expression*
- 1 May 1987
- journal article
- research article
- Published by The Endocrine Society in Molecular Endocrinology
- Vol. 1 (5) , 363-370
- https://doi.org/10.1210/mend-1-5-363
Abstract
The rat corticotropin releasing hormone (CRH) gene has been isolated and characterized by DNA sequence analysis. The gene exhibits a structural organization similar to that of the human CRH gene. The nucleotide sequence encoding the entire rat CRH precursor is located on the second exon, while exon I encodes the 5''-untranslated region of the mRNA. Analysis of the nucleotide sequence homology between the human and rat CRH genes reveals several highly conserved regions including the CRH peptide-encoding sequence and the 5''-flanking sequence. RNA blot analysis demonstrates that CRH mRNA can be observed in numerous regions of the rat brain as well as the spinal cord, adrenal gland, pituitary, and testis.This publication has 24 references indexed in Scilit:
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