Preparation of 5‐substituted benzylbarburituric acids and investigation of the effect of the benzyl and substituted benzyl groups on the acidity of barbituric acid
- 1 January 1986
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 23 (1) , 9-11
- https://doi.org/10.1002/jhet.5570230103
Abstract
The acidity of 5‐benzylbarbituric acid and a series of 5‐substituted benzylbarbituric acids has been determined in 50% ethanol/water and they were found to be more acidic than barbituric acid. The pKas of these derivatives obey Hammett's equation indicating that their acidity is affected by substituents in the same manner as the benzoic acid ionization constants. A synthesis of these acids is described.Keywords
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