Evidence for transcriptional regulation of dihydroorotic acid dehydrogenase in Saccharomyces cerevisiae

Abstract
Two yeast DNA fragments carrying the URA 1 gene have been isolated. URA 1 mRNA levels were measured in wild-type yeast and ppr 1 (constitutive for DHOdehase synthesis) strains. Results favour the hypothesis that ppr 1 increases the transcription of URA 1. The corresponding E. coli PYR D gene has also been cloned.