Electron-Microscopic Changes across Irradiated Rat Intestinal Villi

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Abstract
Neither thiamine transport nor the fine structure in the epithelium of the villi was significantly altered 1 hour or 1 day after 525 r of total-body irradiation, even though focal edema occurred between epithelial cells and between core cells of the lamina propria. On day 3 thiamine transport was lowest when focal areas of new, immature, abnormal epithelial cells appeared on dehydrated villi. A partial recovery of intestinal thiamine transport on days 4 to 6 was not prevented by the reappearance of edematous changes and the development of microscopic hemorrhage. Sustained incomplete recovery of intestinal thiamine transport on days 10 to 17 was attributed to focal areas of epithelial degeneration.