Recombinant γ‐interferon inhibits prostaglandin‐mediated and parathyroid hormone‐induced bone resorption in cultured neonatal mouse calvaria
- 17 June 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 185 (2) , 287-290
- https://doi.org/10.1016/0014-5793(85)80924-8
Abstract
A role of γ-interferon in the bone remodeling process can be implicated from its interference with bone resorptive processes in cultured neonatal mouse calvaria. The immune interferon is an efficient inhibitor of endogenous prostaglandin synthesis, particularly after stimulation by thrombin or arachidonic acid, and, in addition, has a calcitonin-like inhibitory effect on PTH-induced osteoclastic bone résorption. γ-Interferon Bone resorption Neonatal mouse calvaria Prostaglandin synthesis Parathyroid hormone CalcitoninKeywords
This publication has 15 references indexed in Scilit:
- Mechanisms of fever induced by recombinant human interferon.Journal of Clinical Investigation, 1984
- Inhibition of parathormone-stimulated bone resorption by Type I interferonBiochemical and Biophysical Research Communications, 1984
- Effect of Interferon on Heterotopic New Bone Formation in MiceJournal of Interferon Research, 1984
- Prostaglandin E2 — like activity and senile osteoporosisProstaglandins, Leukotrienes and Medicine, 1983
- Thrombin, a stimulator of bone resorptionBioscience Reports, 1983
- Bone resorption and prostaglandin production by mouse calvaria in vitro: Response to exogenous prostaglandins and their precursor fatty acidsProstaglandins, 1981
- Lymphokine-mediated bone resorption requires endogenous prostaglandin synthesis.The Journal of Experimental Medicine, 1981
- Bone Resorbing Activity in Supernatant Fluid from Cultured Human Peripheral Blood LeukocytesScience, 1972
- Thyrocalcitonin and bone resorptionThe American Journal of Medicine, 1967