Hyperthermia-Induced Seizures in the Rat Pup: A Model for Febrile Convulsions in Children
- 28 August 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 213 (4511) , 1034-1036
- https://doi.org/10.1126/science.7268407
Abstract
Seizures were produced in rat pups by ambient hyperthermia. Seizure threshold temperatures, measured rectally and intracerebrally, increased between 2 and 10 days of age. Electrocortical paroxysmal discharges were confirmed in hyperthermic 6- and 10-day-old pups. The increasing resistance to hyperthermic seizures with maturation and the electroencephalographic changes induced by hyperthermia are similar to those in young children.Keywords
This publication has 12 references indexed in Scilit:
- Neurologic sequelae of experimental febrile convulsionsNeurology, 1978
- Febrile Seizures and Later Intellectual PerformanceArchives of Neurology, 1978
- THE EFFECT OF HYPERTHERMIA UPON OXYGEN CONSUMPTION AND UPON ORGANIC PHOSPHATES, GLYCOLYTIC METABOLITES, CITRIC ACID CYCLE INTERMEDIATES AND ASSOCIATED AMINO ACIDS IN RAT CEREBRAL CORTEXJournal of Neurochemistry, 1976
- The Child Who Convulses with FeverPediatric Clinics of North America, 1974
- Maturation of epileptiform activityElectroencephalography and Clinical Neurophysiology, 1968
- Evidence of injury by heat in mammalian tissuesAmerican Journal of Physiology-Legacy Content, 1964
- Electroencephalographic changes in children with artificially induced hyperthermiaThe Journal of Pediatrics, 1956
- EFFECT OF TEMPERATURE ON THE OXYGEN CONSUMPTION OF BRAIN TISSUEJournal of Neurophysiology, 1944
- THE METABOLIC EFFECTS OF POTASSIUM, TEMPERATURE, METHYLENE BLUE AND PARAPHENYLENEDIAMINE ON INFANT AND ADULT BRAINAmerican Journal of Physiology-Legacy Content, 1942