The enzyme-catalysed conversion of anti-benzo[alpyrene-7,8-diol 9,10-oxide into a glutathione conjugate
- 1 December 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 1 (12) , 1075-1080
- https://doi.org/10.1093/carcin/1.12.1075
Abstract
Anti-BP-7, 8-diol 9,10-oxide (r-7, t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[alpyrene) was converted in the presence of a rat-liver supernatant fraction and glutathione into a water-soluble metabolite that was identified as a glutathione conjugate. The formation of the glutathione conjugate appears to be catalysed by glutathione S-transferases, present in the rat-liver supernatant, because the amount of conjugate formed was reduced considerably when anti-BP-7,8-diol 9,10-oxide was incubated with glutathione either in the absence of the supernatant fraction or in the presence of heat-denatured supernatant fraction.Keywords
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