Deposition of inhaled particulate matter in the upper respiratory tract, larynx, and bronchial airways: A mathematical description

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Abstract
A mathematical description of inhaled particle behavior suitable for analysis of factors affecting deposition in the human upper respiratory tract (nasopharyngeal and oropharyngeal compartments), larynx and ciliated airways was presented. When upper respiratory tract and larynx filtering efficiencies were incorporated in the model, theoretical calculations of aerosol deposition agreed with tracheobronchial (TB) data reported in the open literature. The model predicted the sigmoidal shape of TB deposition patterns measured in human subjects, the slopes of the quasilinear segments of these curves and the positions of their 2 asymptotes. The model could be used to evaluate the health effects of toxic airborne particles.