Chronic ingestion of MN3O4by rats: Tissue accumulation and distribution of manganese in two generations
- 1 February 1982
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 9 (2) , 175-188
- https://doi.org/10.1080/15287398209530153
Abstract
Sprague‐Dawley rats were chronically exposed to particulate Mn 3 O 4 through two generations. At specific ages, observations were made of growth, tissue content, and distribution of Mn and Fe as affected by chronic exposure to Mn through an Fe‐sufficient diet and an Fe‐deficient diet. Chronic dietary Mn 3 O 4 resulted in dose‐related increases in Mn accumulation, and a concomitant Fe deficiency promoted Mn accumulation. In general, the addition of substantial amounts of Mn to either diet depressed tissue Fe levels.This publication has 12 references indexed in Scilit:
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