Glucose oxidase as a pharmaceutical antioxidant
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 18 (16) , 1813-1822
- https://doi.org/10.3109/03639049209040904
Abstract
The effect of five antioxidant systems on the rate of oxidation of isoproterenol formulations was studied. In addition to a control, the antioxidants were studied alone and in all possible combinations of two. The systems tested were glucose oxidase, nitrogen, sodium bisulfite, acetylcysteine and thiourea. Glucose oxidase and its combination with nitrogen flushing or thiourea were found to be effective. Acetylcysteine appeared to inactivate glucose oxidase. The combination of sodium bisulfite and thiourea was also effective although nitrogen or thiourea alone were not effective.Keywords
This publication has 5 references indexed in Scilit:
- The Effect of Various Additives on the Stability of Isoproterenol Hydrochloride SolutionsDrug Development and Industrial Pharmacy, 1986
- Sulfurous Acid Salts as Pharmaceutical AntioxidantsJournal of Pharmaceutical Sciences, 1961
- Degradation of Epinephrine Induced by Bisulfite * *School of Pharmacy, University of Wisconsin, Madison, and Parke, Davis and Co., Detroit, Mich.Journal of the American Pharmaceutical Association (Scientific ed.), 1958
- Food Stabilization, Glucose Conversion in Preparation of Albumen Solids by Glucose Oxidase-Catalase SystemJournal of Agricultural and Food Chemistry, 1953
- The mechanism of the action of notatinBiochemical Journal, 1949