Bacterial Activators (Lysokinases) of the Fibrinolytic Enzyme System of Serum.

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Abstract
In a survey test (growth in medium plus fibrin clots, with and without added profibrinolysins) of 77 cultures of 40 bacterial types, fi-brinolysins) of 77 cultures of 40 bacterial types, fibrinolytic phenomena were encountered in 19 types (33 cultures) tested. Attempts to prepare lysokinase by cold alcoholic precipitation of broth cultures of 12 of the above, with study of effects on profibrinolysins of human, dog, and bovine serum origin, merely confirmed previous knowledge that only certain hemolytic streptococci and staphylococci produced the specific activator, the latter acting on dog as well as human prolysin, but neither being able to activate bovine proenzyme. Direct fibrinolytic activity may occur in cultures when (except in the case of Clostridium botulinum. culture filtrates of which are lytic) it is not found in the alcoholic precipitate. The failure to obtain lysokinase in at least 6 types of bacterial cultures which gave good results in the survey test is noted, as is the inability to find a kinase for bovine profibrinolysin.
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