Effect of food, fluid and dosage form on the absorption of 52–522, a potential antianxiety agent, in the dog

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Abstract
The absorption of 52–522 in the dog was studied by measuring blood concentrations of radioactivity after single oral doses of [14C] 52–522 in a capsule with and without water, also as a food-drug mixture, and a solution in polyethylene glycol 400. Absorption was rapid, and its rate moderate with no significant differences in peak times among treatments. The extent of absorption was lowest after the capsulated [14C] 52–522. The solution dose gave elevated blood concentrations, that were statistically significantly different when compared with the capsules. Hence, it appears that the absorption of [14C] 52–522 is governed by the degree of dispersion of drug in the dosage form.

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