Mechanisms of Transcriptional Synergism of Eukaryotic Genes
- 1 April 1996
- journal article
- review article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 27 (4) , 1025-1029
- https://doi.org/10.1161/01.hyp.27.4.1025
Abstract
Abstract The virus-inducible enhancer of the human interferon-β gene has served as an excellent example for the mechanisms controlling the activation and repression of transcription. This enhancer is activated by three different transcription factors that, with the help of the high mobility group protein HMG I(Y), assemble in a unique nucleoprotein complex that interacts as a unit with the basal transcriptional machinery. The assembly of unique enhancer complexes from similar sets of transcription factors may provide the specificity required for regulation of complex patterns of gene expression in higher eukaryotes.Keywords
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